CHARACTERIZATION OF THE NORSPERMIDINE/SPERMIDINE TRANSPORT PROTEIN, POTD1, IN VIBRIO CHOLERAE A Thesis by ALEXANDRIA COLETT RUTKOVSKY
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Spermidine regulates Vibrio cholerae bio¢lm formation via transport and signaling pathways
Vibrio cholerae, the causative agent of the devastating diarrheal disease cholera, canform biofilms on diverse biotic and abiotic surfaces. Biofilm formation is important for the survival of this organism both in its natural environment and in the human host. Development of V. cholerae biofilms are regulated by complex regulatory networks that respond to environmental signals. One of these sign...
متن کاملSpermidine regulates Vibrio cholerae biofilm formation via transport and signaling pathways.
Vibrio cholerae, the causative agent of the devastating diarrheal disease cholera, can form biofilms on diverse biotic and abiotic surfaces. Biofilm formation is important for the survival of this organism both in its natural environment and in the human host. Development of V. cholerae biofilms are regulated by complex regulatory networks that respond to environmental signals. One of these sig...
متن کاملVibrio cholerae NspS, a homologue of ABC-type periplasmic solute binding proteins, facilitates transduction of polyamine signals independent of their transport.
The polyamines norspermidine and spermidine are among the environmental signals that regulate Vibrio cholerae biofilm formation. The effects of these polyamines are mediated by NspS, a member of the bacterial periplasmic solute binding protein superfamily. Almost all members of this superfamily characterized to date are components of ATP-binding cassette-type transporters involved in nutrient u...
متن کاملRelative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation
The polyamine norspermidine is one of the major polyamines synthesized by Vibrionales and has also been found in various aquatic organisms. Norspermidine is among the environmental signals that positively regulate Vibrio cholerae biofilm formation. The NspS/MbaA signaling complex detects extracellular norspermidine and mediates the response to this polyamine. Norspermidine binding to the NspS p...
متن کاملNspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine.
Vibrio cholerae is both an environmental bacterium and a human intestinal pathogen. The attachment of bacteria to surfaces in biofilms is thought to be an important feature of the survival of this bacterium both in the environment and within the human host. Biofilm formation occurs when cell-surface and cell-cell contacts are formed to make a three-dimensional structure characterized by pillars...
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تاریخ انتشار 2012